Allergen Details:
| Allergen name: | Per a 12 |
|---|---|
| Lineage: |
Source: Animalia Arthropoda Order: Blattodea Species: Periplaneta americana (American cockroach) |
| Biochemical name: | Chitinase |
| MW(SDS-PAGE): | 45 kDa |
| Allergenicity: | Sera from 30 of 40 (63.8%) patients reacted to Per a 12 on immunoblots. ELISA inhibition of serum IgE reactivity to the cockroach midgut extract (CME) using purified Per a 12 was significant (40%). Nine of 15 (60%) cockroach-allergic patients had positive SPT reactions to Per a 12. In comparison with healthy control, Per a 12 at 1.0 μg/ml induced approximately up to 5-fold increase in the number of CD63 and CCR3 double-positive cells following incubating it with PBMC from patients with cockroach allergy |
| Allergenicity ref.: | 26361742 |
| Food allergen: | No |
| Date Created: | 2016-02-18 12:00:00 |
| Last Updated: | 2016-10-11 12:57:48 |
| Submitter Info: | |
| Name: | Su An |
| Institution: | Kunming Institute of Zoology, Chinese Academy of Sciences |
| City: | Kunming, China |
| Email: | aslxj@mail.ustc.edu.cn |
| Date: | 2015-05-05 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Per a 12.0101 | KR019686 | AKH04311 |