Allergen Details:
| Allergen name: | Asc s 13 |
|---|---|
| Lineage: |
Source: Animalia Nematoda Order: Ascaridida Species: Ascaris suum (Pig roundworm) |
| Biochemical name: | Glutathione transferase |
| MW(SDS-PAGE): | 23 kD |
| Allergenicity: | 20 of 29 Ascaris ImmunoCAP positive subjects showed IgE binding to GST by ELISA; 12 of 91 non-asthmatic controls were positive by ELISA to GST in vitro IgE binding; 42 of 215 Asmthmatic subjects were positive to GST by ELISA; 3 of 10 asthmatics tested with recombinant GST by Skin Prick test were positive with at least 3mm diameter wheal |
| Allergenicity ref.: | 24223794 |
| Food allergen: | No |
| Date Created: | 2014-09-08 12:00:00 |
| Last Updated: | 2016-10-11 12:53:03 |
| Submitter Info: | |
| Name: | Luis Caraballo |
| Institution: | University of Cartagena, Institute for Immunological Research |
| City: | Cartagena, Columbia |
| Email: | lcaraballog@unicartagena.edu.co |
| Date: | 2014-08-23 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Asc s 13.0101 | X75502.1 | CAA53218 | P46436 |
Recombinant Glutathione transferase (GST) from Ascaris suum and natural GST from Ascaris lumbricoides were used in tests of IgE binding in subjects sensitized to Ascaris extract. Some publications suggest that these two species are one, based on genetics and also proven hybridization. There is some cross reactivity to mite and cockroach GST and this protein.