Allergen Details:
| Allergen name: | Cand b 2 |
|---|---|
| Lineage: |
Source: Fungi Ascomycota Order: Saccharomycetales Species: Candida boidinii (Yeast) |
| Biochemical name: | Peroxisomal membrane protein A |
| MW(SDS-PAGE): | 20 |
| Allergenicity: | 89 patients sensitized to A. fumigatus displayed significantly higher levels of rCand b 2-specific IgE in their serum (mean value: 100 EU/ml; p LESSTHAN 0.005) than 11 control individuals without a history of atopy. |
| Allergenicity ref.: | 9412580 |
| Food allergen: | No |
| Date Created: | 2003-09-01 12:00:00 |
| Last Updated: | 2010-04-29 16:57:55 |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cand b 2.0101 | J04984 | AAA34357 | P14292 |
The allergenicity or IgE binding described in the Hemmann paper (1997) used sera from asthmatic subjects with high IgE to Aspergillus fumigatus Asp f 3. Binding of the 89 subjects to the peroxisomal proteins of Candida boidinii was markedly less (~ 1/2 log greater than control sera for C boidinii), while 2 log higher in binding to Asp f 3. Additionally, the cross-reactive inhibition by Cand b 2 was only 1/100 to 1/1000 compared to Asp f 3 inhibition of binding to Asp f 3.